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Metronidazole has proven proof of mutagenic activity in several in vitro bacterial assay systems. Additionally, a dose-similar boost in the frequency of micronuclei was observed in mice right after intraperitoneal injections. A rise in chromosomal aberrations in peripheral blood lymphocytes was claimed in sufferers with Crohn’s condition who had been dealt with with two hundred to 1200 mg/working day of metronidazole for 1 to 24 months.

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METROGEL® Topical Gel is indicated for topical application in the cure of inflammatory papules and pustules of rosacea.

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The next adverse response is determined throughout article-acceptance use of topical metronidazole. Due to the fact this response is claimed voluntarily from a populace of uncertain measurement, it is not often doable to reliably estimate the frequency or establish a causal connection to drug exposure.